Synergistic interaction of trimethoprim and sulfamethoxazole on Paracoccidioides brasiliensis
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Synergistic interaction of trimethoprim and sulfamethoxazole on Paracoccidioides brasiliensis.
The in vitro interaction of trimethoprim and sulfamethoxazole on clinical isolates of Paracoccidioides brasiliensis was studied. With complete inhibition and a visual endpoint used as the criteria, three of four strains had minimal inhibitory concentrations that indicated resistance to sulfamethoxazole, and all four strains were resistant to trimethoprim. A marked synergism in inhibition was no...
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b a s e don folic acid biosynthetic pathway a mathematical model was made for bacterial growth to describe the synergistic effect between sulfamethoxazole and trimethoprim. The results obtained show a strong synergism at growth inhibiting concentrations of these two drugs. Two cyclic pathways included in the model are responsible for this synergism. The roles of these pathways in producing ...
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b a s e don folic acid biosynthetic pathway a mathematical model was made for bacterial growth to describe the synergistic effect between sulfamethoxazole and trimethoprim. the results obtained show a strong synergism at growth inhibiting concentrations of these two drugs. two cyclic pathways included in the model are responsible for this synergism. the roles of these pathways in producing syne...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1982
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.21.5.852